Determination of Aromatic Retinoic Acid Ethyl Ester in Capsules by UV-1700SPC Ultraviolet Spectrophotometry
Key words: ultraviolet spectrophotometry; aromatic retinoic acid ethyl ester; aesthetic analyzer; UV-1700SPC. Abstract: This study presents a simple and accurate method for determining the content of aromatic retinoic acid ethyl ester in capsules using UV-1700SPC ultraviolet spectrophotometry. The measurement was performed at a wavelength of (306 ± 1) nm. Results showed a good linear relationship between concentration and absorbance in the range of 2–12 μg/mL, with a regression equation of A = 0.06893C – 0.005333 and a correlation coefficient of r = 0.9999. The average recovery rate was 99.9%, with an RSD of 0.74%. The method is simple, precise, and reproducible, making it suitable for quality control of aromatic retinoic acid ethyl ester preparations. Aromatic retinoic acid ethyl ester belongs to the third generation of retinoids and is known for its strong differentiation-inducing properties. It is used in the treatment of severe psoriasis, keratosis, rheumatism, immune rickets, malignant tumors, and leukemia. However, there are no previous reports on the content determination of this compound in pharmaceutical preparations. The proposed method offers a fast and reliable way to analyze its content. Instrument and reagents: UV-1700SPC ultraviolet spectrophotometer, analytical balance, reference substance of aromatic retinoic acid ethyl ester, capsules, anhydrous ethanol (analytical grade), and excipients. Methods and results: - **UV absorption spectrum**: A solution of 10 μg/mL was prepared, and maximum absorption was observed at 306 nm. The absorption peak of the capsule solution matched that of the reference substance, and no interference was found from excipients. - **Standard curve**: Solutions of different concentrations were prepared, and the linear relationship between absorbance and concentration was confirmed. - **Reproducibility test**: Three samples showed low variability with an RSD of 0.25%. - **Recovery test**: The recovery rate was calculated using a standard addition method, showing high accuracy. - **Stability test**: The solution remained stable for up to 24 hours under dark conditions. - **Sample analysis**: The content of the sample was determined using the same procedure. This method is efficient and suitable for routine quality control in pharmaceutical production. Key words: ultraviolet spectrophotometry; aromatic retinoic acid ethyl ester; US analytical instrument; UV-1700SPC
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